MPL Mutation Analysis

Code
MOG-MPLX-01BX
Test
Active-Compendium
81339
Clinical
Oncology,Pathology
<p>Bone Marrow Aspirate: 2 mL in EDTA tube.<br/>
Peripheral Blood: 5 mL in EDTA tube.<br/>
Note: Test is DNA-based. Please select Extract & Hold - DNA If specimen hold service is desired.</p>
Hematologic Diseases
Myeloproliferative neoplasm (MPN)
Molecular
Global
Flag Active
True
Orderable Test Description
<p>This test uses bi-directional sequencing on MPL exon 10 to detect all possible mutations at the W515 and S505 codons, and other mutations throughout the exon. <br><br>
Testing is performed on plasma for increased sensitivity whenever possible.
<br><br>
Test Customization: This test may be ordered separately or as part of the MPN Reflex Panel. </p>
Orderable Turn Around Time
10 Days
Keywords
MPL Mutation
MPL
Meta Description
Bi-directional sequencing of exon 10 of the MPL gene to detect all possible mutations at the W515 and S505 codons, and other mutations throughout the exon. Testing is performed on plasma for increased sensitivity whenever possible.
Orderable Biomarkers
MPL
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["MPL"]}}
Keywords string
MPL Mutation, mpl MPL Mutation Analysis
Title URL
mpl-mutation-analysis
Clinical Significance
MPL W515 mutations are present in JAK2-negative patients with primary myelofibrosis (PMF) or essential thrombocythemia (ET) at a frequency of approximately 1-5%, respectively. The S505 mutation is usually detected in patients with familial essential thrombocythemia.  Mutation analysis helps differentiate reactive conditions from MPNs.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select extract & hold - DNA if specimen hold service is desired. NYS clients please provide date and time of collection.