Code
NTG-ALLX-02CX
Profile
Active-Compendium
81450
88374x2
88374x2
Clinical
Oncology,Pathology
<p>Bone Marrow Aspirate: 2-3 mL in EDTA tube.<br/>
Peripheral Blood: 3-5 mL in EDTA tube.<br/>
H&E slide (required) plus paraffin block.<br/>
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.<br/>
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br/>
Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.<br/>
Note: Test is TNA-based. Please select Extract & Hold - TNA If specimen hold service is desired.<br/>
Note for FFPE: Not validated specimen type for FISH testing.</p>
Peripheral Blood: 3-5 mL in EDTA tube.<br/>
H&E slide (required) plus paraffin block.<br/>
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.<br/>
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.<br/>
Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.<br/>
Note: Test is TNA-based. Please select Extract & Hold - TNA If specimen hold service is desired.<br/>
Note for FFPE: Not validated specimen type for FISH testing.</p>
Flag Active
True
Orderable Test Description
<p>The NeoTYPE ALL Profile analyzes <b>50 genes</b> to detect DNA and RNA alterations through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary interpretation of all results together.<br><br>
<b>SNV/InDel (29 genes)<br><br>
RNA Fusions (34 genes)<br><br>
Copy Number Variations (CNVs) (3 genes)</b><br>
Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes.<br><br>
<b>FISH (2 biomarkers)</b><br>
CRLF2 (Xp22.33/Yp11.32)<br>
EPOR (19p13.2)<br>
(tech-only available)</p>
<b>SNV/InDel (29 genes)<br><br>
RNA Fusions (34 genes)<br><br>
Copy Number Variations (CNVs) (3 genes)</b><br>
Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes.<br><br>
<b>FISH (2 biomarkers)</b><br>
CRLF2 (Xp22.33/Yp11.32)<br>
EPOR (19p13.2)<br>
(tech-only available)</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"RNA Sequencing": {"Fusions": ["BCL11B", "ABL1", "ABL2", "BCR", "CRLF2", "CSF1R", "EPOR", "ETV6", "FGFR1", "FLT3", "IKZF1", "JAK2", "STIL", "MEF2D", "MLLT10", "KMT2A", "NTRK2", "NTRK3", "NTRK1", "PAX5", "PBX1", "NUP98", "PDGFRB", "PDGFRA", "PTK2B", "RUNX1", "TAL1", "TCF3", "NUP214", "TLX3", "TYK2", "ZNF384", "TLX1", "MYB"], "Overexpression": ["CRLF2", "EPOR"]}, "DNA Sequencing": {"SNVs + Indels": ["PAX5", "ABL1", "ABL2", "CDKN2A", "CRLF2", "CSF1R", "EPOR", "FGFR2", "FGFR3", "FLT3", "IKZF1", "IL7R", "JAK1", "JAK2", "JAK3", "NTRK1", "NTRK2", "NTRK3", "PDGFRA", "SH2B3", "PDGFRB", "TP53", "IDH1", "IDH2", "KRAS", "NOTCH1", "NRAS", "PHF6", "FBXW7"], "CNVs": ["CDKN2A", "IKZF1", "TP53"]}, "Fluorescence In Situ Hybridization (FISH)": {"CNVs": ["CRLF2", "EPOR"]}}
Keywords string
Acute lymphoblastic leukemia, Myeloid disorders, heme cancers, hematologic malignancies NeoTYPE® ALL Profile
Title URL
neotype-all-profile
TAT Details
NGS: 14 Days
FISH: 5 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select Extract & Hold - TNA if specimen hold service is desired.