Code
MOG-MYDX-01BZ
Test
Active-Compendium
81305
Clinical
Oncology,Pathology
<p>Bone Marrow Aspirate: 2 mL in EDTA tube.<br/>
Peripheral Blood: 5 mL in EDTA tube.<br/>
H&E slide (required) plus paraffin block.<br/>
Cut Slides: H&E slide (required) plus 5-10 unstained slides cut at 5+ microns.<br/>
Fresh Lymph Node or Needle Core Tissue Biopsy: 0.5-1 cm3 in RPMI.<br/>
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.</p>
Peripheral Blood: 5 mL in EDTA tube.<br/>
H&E slide (required) plus paraffin block.<br/>
Cut Slides: H&E slide (required) plus 5-10 unstained slides cut at 5+ microns.<br/>
Fresh Lymph Node or Needle Core Tissue Biopsy: 0.5-1 cm3 in RPMI.<br/>
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.</p>
Flag Active
True
Orderable Test Description
This test uses bi-directional sequencing on MYD88 exon 5, including detection of the common L265P mutation.
Orderable Turn Around Time
7 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["MYD88"]}}
Keywords string
MYD88, myd , 88, MYD88 Mutation MYD88 Mutation Analysis
Title URL
myd88-mutation-analysis
Clinical Significance
MYD88 mutation is the most common genetic abnormality in the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), detected in 40% of cases. Mutations are rare in the germinal center B-cell-like (GCB) subtype, so mutation analysis can be useful to differentiate between the ABC and GCB subtypes. The L265P mutation is present in >90% of Waldenstrom's macroglobulinemia (WM) and has been associated with increased risk of progression to WM in IgM MGUS patients. MYD88 is also implicated in susceptibility to BTK inhibitors in the treatment of B-cell neoplasms.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired. NYS clients please provide date and time of collection.