Code
FSH-TCLO-01BX
Test
Active-Compendium
Automated Analysis: 88374x1.
Manual Analysis: 88377x1.
Manual Analysis: 88377x1.
Clinical
Pathology
<p>Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Fresh, Unfixed Tissue: Tissue in RPMI.<br/>
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br/>
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br/>
H&E slide (required) plus paraffin block.<br/>
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns.<br/>
Note for Tech Only clients: Please circle H&E slide.<br/>
Note for NYS clients: Cut slides and paraffin block specimens are not accepted.</p>
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Fresh, Unfixed Tissue: Tissue in RPMI.<br/>
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br/>
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br/>
H&E slide (required) plus paraffin block.<br/>
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns.<br/>
Note for Tech Only clients: Please circle H&E slide.<br/>
Note for NYS clients: Cut slides and paraffin block specimens are not accepted.</p>
Flag Active
True
Orderable Test Description
This test uses TCL1 (14q32.1) probes to detect gene abnormalities associated with mature T-cell leukemia, T-cell prolymphocytic leukemia (T-PLL), and adult T-cell leukemia/lymphoma (ATLL).
Orderable Turn Around Time
3-5 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["TCL1"]}}
Keywords string
TCL1, 14q32.1, mature T-cell leukemia, T-cell prolymphocytic leukemia, adult T-cell leukemia TCL1 (14q32.1)
Title URL
tcl1-14q32-1
Clinical Significance
This breakapart probe covers breakpoint regions in the TCL1 (T-cell leukemia) gene cluster on chromosome 14q32 which encompasses TCL1A, TCL1B, and other genes. TCL1 translocations and inversions occur in mature T-cell leukemias including T-cell prolymphocytic leukemia (T-PLL) and adult T-cell leukemia/lymphoma (ATLL). These rearrangements cause gene overexpression due to juxtaposition with TCR-alpha or TCR-beta regulatory elements and contribute to oncogenesis.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.