Low-Grade/Small B-Cell Lymphoma FISH Panel

Code
FSH-LGSB-03BX
Panel
Active-Compendium
Automated Analysis: 88374x4.
Manual Analysis: Codes may differ.
Clinical
Pathology
<p>Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Fresh, Unfixed Tissue: Tissue in RPMI.<br/>
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 4 slides, labeled with specimen type.<br/>
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br/>
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.<br/>
Cut Slides: H&E slide (required) plus 6 unstained slides cut at 4-5 microns.<br/>
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns for single abnormalities.<br/>
Note for Tech Only clients: Please circle H&E slide.</p>
Hematologic Diseases
Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL)
Diffuse large B-cell lymphoma (DLBCL)
Follicular lymphoma
MALT lymphoma
Mantle cell lymphoma (MCL)
Marginal zone B-cell lymphoma (MZL)
Non-Hodgkin lymphoma (NHL)
FISH
Global
Tech Only
Flag Active
True
Orderable Test Description
<p>This panel is designed to detect specific genetic abnormalities commonly associated with non-Hodgkin lymphoma (NHL) and related B-cell lymphomas including B-cell lymphoma, mantle cell lymphoma (MCL), follicular lymphoma, marginal zone lymphoma (MZL), and MALT lymphoma. It includes the following probes:
<br><br>

BCL6 (3q27)<br>
CCND1/IgH t(11;14)<br>
IgH/BCL2 t(14;18)<br>
MALT1 (18q21)<br><br>

Test Customization: Probes for each translocation may be ordered separately.</p>
Orderable Turn Around Time
3-5 Days
Keywords
low grade
b cell
b-cell
b-cell fish
bcell
b cell fish
low grade
low grade b
lymphoma
lymph
small B-cell,
Meta Description
Probes: BCL6 (3q27) | CCND1/IgH t(11;14), IgH/BCL2 t(14;18) | MALT1 (18q21), Probes may be ordered separately., Disease(s): NHL, B-Cell Lymphoma, MCL, follicular lymphoma, MZL, MALT lymphoma
Orderable Biomarkers
BCL6
BCL2/IgH t(14;18)
CCND1(BCL1)/IgH t(11;14)
MALT1 (18q21)
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Translocation(s)": ["BCL2/IgH t(14;18)", "CCND1(BCL1)/IgH t(11;14)", "MALT1 (18q21)"], "Structural Rearrangement(s)": ["BCL6"]}}
Keywords string
low grade, b cell, b-cell, b-cell fish, bcell, b cell fish, low grade, low grade b, Lymphoma, lymph, small B-cell, Low-Grade/Small B-Cell Lymphoma FISH Panel
Title URL
low-grade-small-b-cell-lymphoma-fish-panel
Clinical Significance

This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas (such as large cell anaplastic and Burkitt lymphoma) are not a diagnostic consideration. BCL6 evaluation (included in this panel) can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma.

Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is also within this category, but typically has a peripheral blood lymphocytosis and is better evaluated by the CLL FISH Panel or NeoTYPE CLL Profile.

Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.