Code
FSH-JAKT-01BX
Test
Active-Compendium
Automated Analysis: 88374x1.
Manual Analysis: 88377x1.
Manual Analysis: 88377x1.
Clinical
Pathology
<p>Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Fresh, Unfixed Tissue: Tissue in RPMI.<br/>
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 1 slides, labeled with specimen type.<br/>
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br/>
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.<br/>
Fresh, Unfixed Tissue: Tissue in RPMI.<br/>
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 1 slides, labeled with specimen type.<br/>
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).<br/>
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.</p>
Flag Active
True
Orderable Test Description
This test uses JAK2 (9p24.1) probes to detect gene abnormalities associated with eosinophilia. <br><br>
Test Customization: This probe is also available as part of the ALL FISH Panel (Ph-Like).
Test Customization: This probe is also available as part of the ALL FISH Panel (Ph-Like).
Orderable Turn Around Time
3-5 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"Fluorescence In Situ Hybridization (FISH)": {"Structural Rearrangement(s)": ["JAK2"]}}
Keywords string
JAK2 FISH, jak2 rearrangement, 9p24.1 JAK2 (9p24.1)
Title URL
jak2-9p24-1
Clinical Significance
JAK2 (9p24.1) break-apart test by FISH is useful for detecting JAK2 rearrangements in eosinophilia workup. Eosinophilia is a common feature of the diseases that are recognized by the World Health Organization (WHO) category, Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2.
For analysis of JAK2 mutations for suspected myeloproliferative neoplasms (MPN), consider JAK2 V617F Mutation Analysis with or without reflex to JAK2 Exon 12-14 Mutation Analysis by molecular.
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of collection.